Cataract Formation and Associated Risk Factors in a 71-Year-Old Patient

Posted: October 8th, 2024

Cataract Formation and Associated Risk Factors in a 71-Year-Old Patient.

Cataracts in Elderly Patients with Multiple Comorbidities: A Case Study Analysis

Abstract:
This paper examines a case study of a 71-year-old female patient presenting with progressive bilateral cataracts, complicated by multiple comorbidities including end-stage renal disease (ESRD), hypertension, and diabetes mellitus. The analysis explores the risk factors contributing to cataract formation, evaluates the clinical presentation, and discusses management considerations in the context of recent literature. This case highlights the complexity of cataract management in elderly patients with multiple systemic diseases.

Introduction
Cataracts remain a leading cause of visual impairment worldwide, particularly affecting the elderly population. Recent studies have shed light on the multifactorial nature of cataract development and the interplay between various risk factors (Wang et al., 2024). This case study presents an opportunity to examine the complexities of cataract management in a patient with multiple comorbidities, a scenario frequently encountered in clinical practice.

Case Presentation
The patient is a 71-year-old Caucasian female presenting with a five-year history of gradual, progressive vision deterioration in both eyes. Her medical history is significant for ESRD due to membranous nephropathy, hypertension, type 2 diabetes mellitus, and rheumatoid arthritis. The patient reports worsening vision despite recent prescription changes and the use of brighter lamps. Her right eye exhibits poorer far vision, while the left eye shows compromised near vision and increased sensitivity to glare.

Risk Factors for Cataract Formation
Several contributing factors have increased this patient’s susceptibility to cataract formation:

3.1 Age
Advanced age is the single greatest risk factor for cataract development. Recent research by Jiang et al. (2023) confirms that age-related changes in lens proteins significantly contribute to cataract formation.

3.2 Diabetes Mellitus
The patient’s history of type 2 diabetes, even though diet-controlled, increases her risk of cataract formation. Nawaz et al. (2024) report a significant correlation between diabetes and cataract development, likely due to increased oxidative stress and glycation of lens proteins.

3.3 Chronic Kidney Disease
ESRD has been associated with an increased risk of cataract formation. The exact mechanisms are not fully understood, but may involve metabolic disturbances and increased oxidative stress associated with renal failure (Zhang et al., 2024).

3.4 Hypertension
Uncontrolled hypertension, as evident in this patient, has been linked to an increased risk of cataract formation. Cicinelli et al. (2023) suggest that hypertension may affect lens metabolism and increase oxidative stress in the lens.

3.5 Corticosteroid Use
The patient’s use of prednisone for rheumatoid arthritis management is a known risk factor for cataract development, particularly posterior subcapsular cataracts (Jia et al., 2024).

3.6 Smoking History
Although the patient quit smoking five years ago, her long history of heavy smoking (2 packs per day) likely contributed to cataract formation. Hong et al. (2022) confirmed that smoking increases the risk of cataract development through oxidative damage mechanisms.

3.7 Ultraviolet Light Exposure
While not explicitly mentioned in the case, prolonged UV light exposure is a known risk factor for cataract formation (Cicinelli et al., 2023). The patient’s occupation as a retired university professor may have involved significant time spent outdoors or under artificial lighting.

Clinical Presentation and Diagnosis
The patient’s symptoms and clinical findings are consistent with bilateral cataracts. The right eye exhibits characteristics of a nuclear cataract, with poor far vision but preserved near vision. The left eye presents features of a posterior subcapsular cataract, evidenced by glare sensitivity and halos around lights (Viswanathan et al., 2024).

Visual acuity testing revealed significant impairment, with the right eye at 20/200 and the left eye at 20/60. Slit-lamp examination confirmed the presence of lens opacities in both eyes, corroborating the diagnosis of bilateral cataracts.

Management Considerations
Managing cataracts in this patient requires a comprehensive approach, considering her multiple comorbidities:

5.1 Optimization of Systemic Conditions
Prior to considering surgical intervention, efforts should be made to optimize the patient’s blood pressure control and diabetes management. The current blood pressure readings (170/105 mmHg) indicate poorly controlled hypertension, which may increase surgical risks.

5.2 Renal Function Considerations
The patient’s ESRD and dialysis dependence necessitate careful perioperative planning. Consultation with the patient’s nephrologist is crucial to determine the optimal timing for surgery in relation to her dialysis schedule.

5.3 Surgical Options
Given the significant visual impairment, particularly in the right eye, cataract surgery should be considered. Modern phacoemulsification techniques have shown excellent outcomes even in patients with multiple comorbidities (Wang et al., 2024).

5.4 Intraocular Lens Selection
The choice of intraocular lens (IOL) should take into account the patient’s visual needs and ocular comorbidities. A monofocal IOL may be preferred given the patient’s medical complexity, although multifocal IOLs could be considered if the patient desires reduced dependence on glasses.

5.5 Postoperative Care
Close monitoring of the patient’s renal function, blood pressure, and glucose levels will be essential in the postoperative period. Additionally, the use of topical corticosteroids for postoperative inflammation management should be carefully titrated given the patient’s diabetes.

Conclusion
This case study illustrates the complex interplay of multiple risk factors in cataract formation and the challenges of managing cataracts in elderly patients with significant comorbidities. A multidisciplinary approach, involving ophthalmology, nephrology, and primary care, is essential for optimal outcomes. Future research should focus on developing tailored strategies for cataract management in patients with multiple systemic diseases.

References:

Cicinelli, M. V., Marmamula, S., & Khanna, R. C. (2023). Cataracts. The Lancet, 401(10375), 499-511.

Hong, Y., Chen, Y., Guo, X., & Wu, L. (2022). Prevalence and Risk Factors for Adult Cataract in the Chinese Population: A Systematic Review and Meta-Analysis. Journal of Ophthalmology, 2022, 7547043.

Jiang, C., Li, Y., Chen, Y., Huang, L., Zhang, S., Hu, Y., … & He, M. (2023). Association of Behavioral and Clinical Risk Factors With Incident Cataract and Cataract Surgery: A Prospective Cohort Study. JAMA Ophthalmology, 141(7), 686-694.

Jia, S., Fabian, I. D., Patel, B. C., Stacey, A. W., Khong, J. J., Chiu, S. J., … & Sagoo, M. S. (2024). Risk factors for cataract in retinoblastoma management. British Journal of Ophthalmology, 108(4), 571-576.

Nawaz, Y., Arshad, M., Iqbal, M., Iqbal, R., Nawaz, R., Hanif, A., … & Asif, M. (2024). The Occurrence and Evaluation of Risk Factors Associated with Cataract Development in Type 1 and Type 2 Diabetes Mellitus Patients. Journal of Nutritional Science and Vitaminology, 70(3), 191-197.

Viswanathan, M., Lim, J. S., Ong, J. J., Chiang, J., Ang, M. J., Ong, J. Y., … & Mehta, S. (2024). Cataracts after Ophthalmic and Nonophthalmic Trauma: Incidence and Risk Factors. Military Medicine, 189(5-6), e1009-e1015.

Wang, D., Zhu, H., Guo, Y., Zheng, Y., Yu, J., Jiang, W., … & Wang, N. (2024). The global burden of cataracts and its attributable risk factors from 1990 to 2019. Frontiers in Public Health, 12, 1366677.

Zhang, Y., Wang, J., Li, Y., Wang, L., Jiang, Y., Liu, Y., … & Li, X. (2024). Research progress on the correlation between cataract and nutrition, oxidative stress, micronutrients and inflammatory factors. Frontiers in Nutrition, 11, 1405033.

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PATIENT CASE
Patient’s Chief Complaints
“My vision is getting worse in both eyes. Brighter lamps and the drops that were prescribed three months ago aren’t working anymore, and I think that I am finally going to need eye surgery.”

HPI
Dr. EGB is a 71-year-old white woman who has made an appointment with her ophthalmologist for further evaluation of her cataracts. She has a five-year history of gradual and progressive deterioration of vision in both eyes. The right eye is worse than the left. She reports that, even with a change in prescription for eyeglasses less than five months ago, “objects keep getting fuzzier. Far-vision is still relatively good in my left eye but near-vision has gotten noticeably worse. Near-vision is good in my right eye but far-vision is getting bad. My left eye is also susceptible to glare, and I see halos around lights with it.” The patient has been followed for some time for chronic renal insufficiency related to membranous nephropathy and is being treated with dialysis. She recently reported for her annual physical exam and was found to have gained 23 pounds in the last 12 months. She has a history of refractory hypertension that required multiple medications before BP was adequately regulated. She has a home BP monitor, but often forgets to perform her BP checks. Earlier today, her home BP measurement was 165/96 mm Hg.

PMH

ESRD (chronic membranous glomerulonephritis)
IV access difficulties
Anemia secondary to CRF
HTN
Hyperlipidemia
Type 2 DM—diet-controlled
AMI ×2; coronary artery angioplasty 9 years ago
Rheumatoid arthritis
S/P appendectomy
CASE STUDY: CATARACTS
For the Disease Summary for this case study, see the CD-ROM.

FH

Father had HTN and died from AMI at age 69; negative for cataracts
No information available for mother
One brother at age 64 is alive with HTN and DM
Has four daughters from previous marriage (all alive and healthy) and one son who committed suicide
SH

Divorced and remarried, lives with husband
Retired university professor and surgical pathologist; still writes textbooks
Smoker, quit 5 years ago, previously 2 ppd
Occasional glass of wine with dinner
No history of illicit drug use
ROS

States that overall she is “doing okay and holding her own, albeit not the best”
Unremarkable, except for vision problems at this time
Meds

Diltiazem CD 120 mg po BID
Atorvastatin 20 mg po QD
Furosemide 160 mg po QD
EC ASA 325 mg po QD
Prochlorperazine 10 mg po TID PRN
Nitroglycerin 0.4 mg SL PRN
Calcium acetate 667 mg 2 gel caps po PC
Nitroglycerin transdermal patch 0.4 mg QD at night with removal in AM
Acetaminophen 650 mg po QID PRN
Clonidine 0.2 mg po TID but not before dialysis
Nabumetone 750 mg 2 tabs Q HS
Prednisone 5 mg ½ tab po Q AM
Methotrexate 2.5 mg 6 tabs po once a week
Folic acid 1 mg po QD
Allergies

IV dye → worsened renal function (4 years ago)
Codeine intolerance → nausea and vomiting
Patient Case Questions

Identify seven contributing factors that have increased susceptibility to cataract formation in this patient.
Which of the seven risk factors that you listed above is the single greatest risk factor for cataracts?
Match the pharmacotherapeutic agents in the left-hand column directly below with the medical conditions in the right-hand column.
a. Diltiazem, furosemide, clonidine → coronary artery disease
b. ASA, nitroglycerin → rheumatoid arthritis
c. Nabumetone, prednisone, methotrexate → hyperlipidemia, folic acid
d. Atorvastatin → hypertension
Why is the patient taking folic acid?
PE and Lab Tests

Snellen Visual Acuity Examination
Right eye: 20/200
Left eye: 20/60
Swinging Flashlight Test
Positive each eye
Slit-Lamp Examination
Lid margins were without inflammation, each eye
Cornea clear and smooth, each eye
Lenses: opacity noted in center of right lens; opacity noted in back of left lens under the capsule
Iris round and without neovascularization or abnormality, each eye
Vitreous examination: clear, each eye
Color vision: WNL, each eye
Lens position: positive for subluxation, each eye
General

Obese white woman who appears her stated age and is in NAD
Vital Signs

BP 170/105 right arm, sitting
BP 165/103 left arm, sitting
P 86
T 98.4°F
WT 194 lbs
Skin

Warm and dry
Good turgor
HEENT

Eyes are negative for pain and redness
PERRLA
EOMI
Arteriolar narrowing on funduscopic exam
Negative for hemorrhages, exudates, or papilledema
Oropharynx clear
Oral mucosa pink and moist
Chest

CTA bilaterally
Cardiac

RRR
S1 and S2 normal
Negative for S3 and S4
Negative for murmurs and rubs
Abdomen

Obese, soft, and non-tender with no guarding
Bowel sounds present
Negative for HSM, masses, and bruits
Genit/Rect

Stool heme negative
MS/Extremities

Negative for CCE
Capillary refill <2 sec
Age-appropriate strength and ROM
Neuro

A & O ×3
Moderately subnormal sensation in lower legs
CNs II–XII intact
Laboratory Blood Test Results

Na: 135 meq/L
K: 3.8 meq/L
Cl: 102 meq/L
HCO3: 23 meq/L
BUN: 72 mg/dL
Cr: 9.1 mg/dL
Glu, fasting: 109 mg/dL
Ca: 8.7 mg/dL
Hb: 9.1 g/dL
Hct: 27%
Mg: 2.4 mg/dL
Phos: 2.6 mg/dL
Plt: 229 × 10³/mm³
Alb: 3.4 g/dL
Patient Case Questions
5. Identify four abnormal laboratory blood test results that are consistent with a diagnosis of chronic renal failure.
6. Account for the “moderately subnormal sensation in the lower legs.”
7. Is the cataract in the left eye more likely to be subcapsular, nuclear, or cortical?
8. Is the cataract in the right eye more likely to be subcapsular, nuclear, or cortical?
9. Is the cataract in the left eye more likely to be mature, immature, or incipient?
10. Is the cataract in the right eye more likely to be mature, immature, or incipient?
11. What probably caused the “arteriolar narrowing” that was observed with funduscopy?
12. Is hypertension in this patient well regulated?