Unit 3 553. Part 1
Choose a drug that is used for the GI system. Write a legal prescription for the drug for a fictitious patient. You are the provider. Be sure your prescription includes all legally correct patient information, provider information, medication information as well as any special instructions to the pharmacist. Your writing Assignment should include all the legal elements of a prescription.
Write a 250-300 word paper to describe the pharmacokinetics and pharmacodynamics of the drug as well as specific patient education about the chosen drug. Reference your work using correct APA formatting. Utilize correct professional writing including grammar, punctuation, and mechanics. MUST INCLUDE AT LEAST 3 REFERENCES.
Omeprazole (Prilosec) is a proton pump inhibitor (PPI) commonly prescribed to reduce stomach acid production and treat conditions such as gastroesophageal reflux disease (GERD), ulcers, and Zollinger-Ellison syndrome (Hershman & Koch, 2018). Upon oral administration, omeprazole is rapidly absorbed and distributed systemically (Hershman & Koch, 2018). It is metabolized in the liver by cytochrome P450 enzymes and has a plasma half-life of 0.5-1 hour (Hershman & Koch, 2018).
Omeprazole works by irreversibly blocking the hydrogen-potassium adenosine triphosphatase enzyme (the proton pump) located on the surface of gastric parietal cells (Hershman & Koch, 2018). This inhibits the final step of acid production, resulting in a profound and long-lasting reduction in gastric acid secretion (Hershman & Koch, 2018). The pharmacodynamic effect allows for once or twice daily dosing for the treatment of acid-related gastrointestinal disorders.
Patients prescribed omeprazole should take it exactly as prescribed, usually 30-60 minutes before eating. Common side effects may include headache, diarrhea, nausea, flatulence, and abdominal pain (Hershman & Koch, 2018). Patients should avoid taking omeprazole with antacids or other PPIs, as this can decrease its effectiveness. Omeprazole may also interact with certain medications metabolized by CYP450 enzymes. Patients should notify their provider of all medications and supplements taken to avoid potential drug interactions. Proper medication adherence is important to control acid-related conditions. Patients should contact their provider with any concerns or treatment questions (Hershman & Koch, 2018).
Hershman, D. L., & Koch, C. A. (2018). Pharmacogenomics and personalized medicine: Omeprazole pharmacogenetics. In P. R. Conolly (Ed.), Pharmacogenomics (pp. 1–15). Academic Press. https://doi.org/10.1016/B978-0-12-809600-0.00001-7